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Leaf Endophytes and Their Bioactive Compounds

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Symbiotic Soil Microorganisms

Part of the book series: Soil Biology ((SOILBIOL,volume 60))

Abstract

Endophytes can reside in every part of a plant and show mutualistic relationship but leaf tissue is considered as an ideal habitat for such microorganisms. Endophytic microflora is a great source of secondary metabolites that can have various biological activities like antibacterial, antifungal, anticancerous, etc. This chapter focuses on such endophytic microbes that inhabit leaf tissues and produce numerous bioactive compounds. Further various classes of secondary metabolites obtained from leaf endophytes are discussed along with some applications of the bioactive compounds.

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References

  • Abubakar S, Ndana RW, Afolabi AS (2017) Bioprospective potentials of endophytic fungi Penicillium spp. isolated from leaves of Azadirachta indica (A. Juss). Int J Biol Res 5:15–21

    Google Scholar 

  • Bacon CW (1988) Procedure for isolating the endophyte from tall fescue and screening isolates for ergot alkaloids. Appl Environ Microbiol 54(11):2615–2618

    Article  CAS  Google Scholar 

  • Bagyalakshmi TA, Ramesh V, Arivudainambi USE, Rajendran A (2012) A novel endophytic fungus Pestalotiopsis sp. inhibiting Pinus canariensis with antibacterial and antifungal potential. Int J Adv Life Sci 1:1–7

    Google Scholar 

  • Barros FAP, Rodrigues-Filho E (2005) Four spiroquinazoline alkaloids from Eupenicillium sp. isolated as an endophytic fungus from leaves of Murraya paniculata (Rutaceae). Biochem Syst Ecol 33(3):257–268

    Article  Google Scholar 

  • Bayman P, Lebron L, Tremblay RL, Lodge DJ (1997) Variation in endophytic fungi from roots and leaves of Lepanthes (Orchidaceae). New Phytol 135:143–149

    Article  Google Scholar 

  • Bisht R, Sharma D, Agarwal PK (2016) Antagonistic and antibacterial activity of endophytic fungi isolated from needle of Cupressus torulosa D. Don. Asian J Pharm Clin Res 9(3):282–288

    CAS  Google Scholar 

  • Chareprasert S, Piapukiew J, Thienhirun S, Whalley AJS, Sihanonth P (2006) Endophytic fungi of teak leaves Tectona grandis L. and rain tree leaves Samanea saman Merr. World J Microbiol Biotechnol 22(5):481–486

    Article  Google Scholar 

  • Chatterjee S, Ghosh R, Mandal NC (2019) Production of bioactive compounds with bactericidal and antioxidant potential by endophytic fungus Alternaria alternata AE1 isolated from Azadirachta indica A. Juss. PLoS One 14(4):e0214744. https://doi.org/10.1371/journal.pone.0214744

    Article  CAS  Google Scholar 

  • Chutulo EC, Chalannavar RK (2018) Endophytic mycoflora and their bioactive compounds from Azadirachta indica: a comprehensive review. J Fungi 4:42

    Article  Google Scholar 

  • Croteau R, Kutchan TM, Lewis NG (2000) Natural products (secondary metabolites). In: Buchanan B, Gruissem W, Jones R (eds) Biochemistry & molecular biology of plants. American Society of Plant Physiologists, pp 1250–1318

    Google Scholar 

  • Dasari TR, Inamdar SM, Pawar KV (2015) Study on production of bioactive compounds and plant promoting ability of endophytes isolated from Rosa sp. and Mangifera indica. Int J Curr Microbiol App Sci 2:136–143

    Google Scholar 

  • Deshmukh SK, Mishra PD, Kulkarni A (2009) Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus. Chem Biodivers 6(5):784–789

    Article  CAS  Google Scholar 

  • Deshmukh SK, Verekar SA, Bhave SV (2015) Endophytic fungi: a reservoir of antibacterials. Front Microbiol 5(715):1–43

    Google Scholar 

  • Devi NN, Singh MS (2013) GC-MS analysis of metabolites from endophytic fungus Colletotrichum gloeosporioides isolated from Phlogacanthus thyrsiflorus Nees. Int J Pharm Sci 23(2):392–395

    Google Scholar 

  • Ding Z, Tao T, Wang L, Zhao Y, Huang H, Zhang D, Liu M, Wang Z, Han J (2019) Bioprospecting of novel and bioactive metabolites from endophytic fungi isolated from rubber tree ficus elastica leaves. J Microbiol Biotechnol 29(5):731–738

    Article  CAS  Google Scholar 

  • Fernandes MDRV, Silva TAC, Pfenning LH, Costa-Neto CMD, Heinrich TA et al (2009) Biological activities of the fermentation extract of the endophytic fungus Alternaria alternata isolated from Coffea arabica L. Braz J Pharm Sci 45(4):677–685

    Article  Google Scholar 

  • Garcia A, Rhoden SA, Bernardi-Wenzel J, Orlandelli RC, Azevedo JL, Pamphile JA (2012) Antimicrobial activity of crude extracts of endophytic fungi isolated from medicinal plant Sapindus saponaria L. J Appl Pharm Sci 2(10):35–40

    Google Scholar 

  • Geetanjali (2017) Exploring the endophytic fungi for bioactive metabolites: an emerging paradigm. IJARSE 6(12):1815–1822

    Google Scholar 

  • Gherbawy Y, Gashgari R (2014) Molecular characterization of endophytic fungi from Calotropis procera plants in Taif region (Saudi Arabia) and their antifungal activities. Plant Biosyst 148(6):1085–1092

    Article  Google Scholar 

  • Gouda S, Das G, Sen SK, Shin HS, Patra JK (2016) Endophytes: a treasure house of bioactive compounds of medicinal importance. Front Microbiol 7:1538

    Article  Google Scholar 

  • Hata K, Sone K (2008) Isolation of endophytes from leaves of Neolitsea sericea in broadleaf and conifer stands. Mycoscience 49(4):229–232

    Article  Google Scholar 

  • Hussein RA, El-Anssary AA (2018) Plants secondary metabolites: the key drivers of the pharmacological actions of medicinal plants. Intech, London. https://doi.org/10.5772/intechopen.76139

    Book  Google Scholar 

  • Ibrahim M, Kaushik N, Sowemimo A, Chhipa H, Koekemoer T, Venter M, Odukoya OA (2017) Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa. Pharm Biol 55(1):1590–1595

    Google Scholar 

  • Jung HJ, Kim Y, Lee HB, Kwon HJ (2015) Antiangiogenic activity of the lipophilic antimicrobial peptides from an endophytic bacterial strain isolated from red pepper leaf. Mol Cells 38(3):273–278

    Article  CAS  Google Scholar 

  • Kandel SL, Joubert PM, Doty SL (2017) Bacterial endophyte colonization and distribution within plants. Microorganisms 5:77

    Article  Google Scholar 

  • Li GH, Yu ZF, Li X, Wang XB, Zheng LJ, Zhang KQ (2007) Nematicidal metabolites produced by the endophytic fungus Geotrichum sp. AL4. Chem Biodivers 4:1520–1524

    Article  CAS  Google Scholar 

  • Li F, He X, Sun Y, Zhang X, Tang X, Li Y, Yi Y (2019) Distinct endophytes are used by diverse plants for adaptation to karst regions. Sci Rep 9:5246. https://doi.org/10.1038/s41598-019-41802-0

    Article  CAS  Google Scholar 

  • Manganyi MC, Tchatchouang CDK, Regnier T, Bezuidenhout CC, Ateba CN (2019) Bioactive compound produced by endophytic fungi isolated from Pelargonium sidoides against selected bacteria of clinical importance. Mycobiology 47(3):335–339

    Article  Google Scholar 

  • Ohloff G (1990) Riechstoffe und Geruchssinn. Die molekulare Welt der Düfte, Springer, Berlin, ISBN 3-540-52560-2. English translation: Scent and Fragrances: The Fascination of Odors and Their Chemical Perspectives. New York: Springer; 1994

    Google Scholar 

  • Pannacione DG, Cipoletti JR, Sedlock AB, Blemings KP, Schardi CL, Machado C, Seidel GE (2006) Effects of ergot alkaloids on food preference and satiety in rabbits, as assessed with gene-knockout endophytes in perennial ryegrass (Lolium perenne). J Agric Food Chem 54(13):4582–4587

    Article  Google Scholar 

  • Santos IP, Silva NL, Silva MV, Araujo JM, Cavalcant MSI, Lima VM (2015) Antibacterial activity of endophytic fungi from leaves of Indigofera suffruticosa Miller (Fabaceae). Front Microbiol 6(350):1–7

    Google Scholar 

  • Sharma D, Pramanik A, Agarwal PK (2016) Evaluation of bioactive secondary metabolites from endophytic fungus Pestalotiopsis neglecta BAB-5510 isolated from leaves of Cupressus torulosa D.Don. 3 Biotech 6(2):210

    Article  Google Scholar 

  • Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216

    Article  CAS  Google Scholar 

  • Strobel G, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67:257–268

    Article  CAS  Google Scholar 

  • Subban K, Subramani R, Johnpaul M (2013) A novel antibacterial and antifungal phenolic compound from the endophytic fungus Pestalotiopsis mangiferae. Nat Prod Res 27(16):1445–1449. https://doi.org/10.1080/14786419.2012.722091

    Article  CAS  Google Scholar 

  • Taylor JE, Hyde KD, Jones EBG (1999) Endophytic fungi associated with the temperate palm Trachycarpus fortunei within and outside its natural geographical range. New Phytol 142(2):335–346

    Article  Google Scholar 

  • Tenguria RK, Khan FN (2011) Distribution of endophytic fungi in leaves of Azadirachta indica A. Juss. (Neem) of Panchmarhi biosphere reserve. Curr Bot 2:27–29

    Google Scholar 

  • Verma VC, Gond SK, Kumar A, Kharwar RN, Boulanger LA, Strobel GA (2011) Endophytic fungal flora from roots and fruits of an Indian Neem plant Azadirachta indica A. Juss, and impact of culture media on their isolation. Indian J Microbiol 51:469–476

    Article  Google Scholar 

  • Wang LW, Zhang YL, Lin FC, Hu YZ, Zhang CL (2011) Natural products with antitumor activity from endophytic fungi. Mini Rev Med Chem 11(12):1056–1074. https://doi.org/10.2174/138955711797247716

    Article  CAS  Google Scholar 

  • Zhang HW, Song YC, Tan RX (2006) Biology and chemistry of endophytes. Nat Prod Rep 23:753–771

    Article  CAS  Google Scholar 

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Correspondence to Payal Mehtani .

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Mathur, P., Mehtani, P., Sharma, C. (2021). Leaf Endophytes and Their Bioactive Compounds. In: Shrivastava, N., Mahajan, S., Varma, A. (eds) Symbiotic Soil Microorganisms. Soil Biology, vol 60. Springer, Cham. https://doi.org/10.1007/978-3-030-51916-2_9

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