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Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method

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8th International Conference on the Development of Biomedical Engineering in Vietnam (BME 2020)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 85))

Abstract

Berberine is commonly used in Eastern countries due to its various biological activities and low cost. However, low permeability has limited its bioavailability. This study was conducted to fabricate solid lipid nanoparticles (SLNs) containing berberine by spray-drying method to enhance its absorption in the human body. SLNs containing berberine was prepared by stearic acid as a solid lipid base and various surfactants. Then, the aqueous dispersion of SLNs was converted into powders to be stored over a long time by the spray-drying method with carbohydrate carriers. The spray-drying parameters such as the inlet and outlet temperatures, the blower speed, the atomizing pressure, the feeding rate were optimized. The nanoparticles physicochemical properties were evaluated before and after the spraying process. The lipid nanoparticles containing berberine were successfully prepared by the spray-drying method with a small particle size (around 230 nm), zeta potential (approximately −30 mV), and homogenous dispersion (polydispersity index just above 0.12). The optimized spray drying parameters were Tinlet/outlet of 110/65 °C, the blower of 0.58 m3/min, atomizing of 20 kPa, and feeding rate of 0.1 L/h. The resulted SLNs exhibited good physical stability and redispersion. The collected SLNs by spray-drying could be considered a potential drug delivery system to enhance berberine absorption into our human body.

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Acknowledgements

This research is funded by International University, Vietnam National University Ho Chi Minh City under grant number: SV2019-BME-09/HĐ-KHCN.

This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number NCM2020-28-01”.

Conflicts of Interest

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Pharmaceutical Engineering Lab, School of Biomedical Engineering, International University—Vietnam National University Ho Chi Minh City, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

    Mai Chau-Ngoc Nguyen, Khoa Nguyen-Manh Le, Ngan Thi-Thu Huynh, Tham Thi-Thanh Nguyen, Hoa Thi-Xuan Bui & Van Hong Nguyen

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  1. Mai Chau-Ngoc Nguyen
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  2. Khoa Nguyen-Manh Le
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  3. Ngan Thi-Thu Huynh
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  4. Tham Thi-Thanh Nguyen
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  5. Hoa Thi-Xuan Bui
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  6. Van Hong Nguyen
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Correspondence to Van Hong Nguyen .

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Editors and Affiliations

  1. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Vo Van Toi

  2. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Thi-Hiep Nguyen

  3. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Vong Binh Long

  4. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Ha Thi Thanh Huong

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Nguyen, M.CN., Le, K.NM., Huynh, N.TT., Nguyen, T.TT., Bui, H.TX., Nguyen, V.H. (2022). Solid Lipid Nanoparticles Containing Berberine by Spray-Drying Method. In: Van Toi, V., Nguyen, TH., Long, V.B., Huong, H.T.T. (eds) 8th International Conference on the Development of Biomedical Engineering in Vietnam. BME 2020. IFMBE Proceedings, vol 85. Springer, Cham. https://doi.org/10.1007/978-3-030-75506-5_25

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  • DOI: https://doi.org/10.1007/978-3-030-75506-5_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-75505-8

  • Online ISBN: 978-3-030-75506-5

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